Frequently Asked Questions

The Trial-Ready Cohort-Down Syndrome, or TRC-DS, is a community of potential clinical trial volunteers who could help find a cure for Alzheimer’s disease in people with Down syndrome. TRC-DS matches people with Down syndrome to clinical trials related to Alzheimer’s disease. TRC-DS routinely monitors volunteers for any changes to their brain health or function over time through blood tests and brain imaging to eventually match them with applicable Alzheimer’s disease clinical trials. Because they are routinely screened, it allows researchers to fast-track TRC-DS volunteers for enrollment in qualifying clinical studies as soon as they are eligible and matched with one.
Healthy volunteers between the ages of 35 and 55 with Down syndrome can join TRC-DS as the initial step towards participating in new Alzheimer’s disease clinical trials. Interested volunteers should:
 
  1. Contact the research center closest to them to discuss eligibility
  2. If invited, volunteers visit their nearest research center for an in-person evaluation to determine eligibility for TRC-DS
  3. Following the evaluation, eligible TRC-DS volunteers become part of a group regularly assessed once every 16 months with physical exams, medical tests (such as a blood draw and brain imaging scans), and memory skills assessments to measure changes in their brain health and function.

Researchers are looking for healthy volunteers between the ages of 35 and 55 to participate in TRC-DS.

 
Eligible volunteers:
 
  • Are healthy adults between the ages of 35 to 55 with Down syndrome;
  • Have an interest in supporting clinical research; and
  • Will visit their nearest research center once every 16 months for physical exams like blood pressure checks and blood draws, and memory skills tests to measure changes in their brain health and function.
Because people with Down syndrome have the same brain changes as patients with Alzheimer’s disease, they are at very high risk for Alzheimer’s disease dementia and are an important population to consider as we develop therapies for Alzheimer’s research. In fact, people with Down syndrome helped researchers discover the genetic relationship between amyloid (a protein in the brain) buildup and Alzheimer’s disease almost 40 years ago.
 
TRC-DS is recruiting younger individuals for clinical studies because people with Down syndrome develop Alzheimer’s much earlier than others who develop the disease. If research could uncover ways to slow or prevent the progression of Alzheimer’s disease in people with Down syndrome, especially at an earlier age, it could also help us understand better ways to target Alzheimer’s disease in others.
Interested volunteers and their families can contact the research center nearest them for more information on TRC-DS, steps to eligibility, and/or to schedule an in-person evaluation, if invited. If there is no research center nearby, individuals should visit this site periodically for potential future opportunities.