People with Down syndrome helped researchers discover breakthroughs in Alzheimer’s disease almost 40 years ago.

It is now time to bring the latest discoveries in the Alzheimer’s field to those with Down


The Trial-Ready Cohort-Down Syndrome (TRC-DS) is a community of potential clinical trial participants who could help find a cure for Alzheimer’s disease.

As many as nine in 10 people with Down syndrome develop Alzheimer’s disease

There is no cure for Alzheimer’s disease. That’s why participants are needed to support new research into the connection between the two.

Portrait of Young Hispanic Female Worker at Pasta Factory

TRC-DS needs healthy adults with Down syndrome to advance therapies and potential cures

TRC-DS needs healthy adults between the ages of 25 and 55 with Down syndrome to participate and become part of a larger movement advancing Alzheimer’s disease therapies and potential cures for people with Down syndrome.

Participants are needed

Researchers want to bring the most promising treatments to people with Down syndrome, but participants are needed.

Volunteers are needed

How to Join






The nearest research center



Eligible participants may be paired with a study

This project is funded by the National Institutes of Health’s INCLUDE (INvestigation of Co-occurring conditions across the Lifespan to Understand Down syndromE) project, in partnership with:

Interested participants should contact their nearest TRC-DS research location